Program

IRCCS Italian Network of Neuroscience and Neurorehabilitation (RIN): the Virtual National Institutes
Fabrizio Tagliavini (Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy)

Image based models for unravelling the heterogeneity of neurodegenerative disease
Daniel C. Alexander (University College London, London, United Kingdom)

Big data collections and AI analysis: the neuGRID and GAAIN platforms
Alberto Redolfi (IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy)

Deciphering the genetic component of Alzheimer’s disease: potential implications in personalised medicine?
Jean-Charles Lambert (Institut Pasteur de Lille, Université de Lille, Lille, France)

Lactate metabolism in the control of microglial function
Rosa Chiara Paolicelli (University of Lausanne, Lausanne, Switzerland)

Mitochondrial network dynamics in reactive astrocytes
Matteo Bergami (CECAD Research Center, University Hospital Cologne, Germany)

Environmental stimuli shape microglial plasticity in glioma
Stefano Garofalo (La Sapienza University of Rome, Rome, Italy)

Development of organ-specific therapies for brain metastasis based on altered molecular pathways in reactive astrocytes
Neibla Priego (Spanish National Cancer Research Centre CNIO, Madrid, Spain)

Longitudinal effects of early social adversity on brain and behavioural development in rhesus macaques
Holly Rayson (Claude Bernard University Lyon 1, Bron, France)

Role of Monkey prefrontal and premotor cortices in guiding behavior based on social information
Alfonso Gravante (University of Parma, Parma, Italy)

Frontal pole activity of macaque monkeys in a social interactive task
Simon Nougaret (Sapienza University of Rome, Rome, Italy)

Widespread and interactive social gaze monitoring in the primate brain
Olga del Monte (University of Turin, Turin, Italy and Yale University, New Haven, USA)

Peripheral immune changes during Parkinson’s disease
Marina Romero Ramos (Aarhus University, Aarhus, Denmark)

Active and passive immunotherapy with a novel epitope against N-truncated amyloid-peptides in preclinical mouse models
Thomas A. Bayer (Georg August University, Göttingen, Germany)

Targeting increased levels of APP Tyr682 phosphorylation in Alzheimer’s disease patients: what are peripheral cells telling the brain?
Carmela Matrone (University of Naples Federico II, Naples, Italy)

Circulating biomarkers in neurodegenerative diseases, a flow cytometry approach
Peppino Mirabelli (IRCCS SDN, Naples, Italy)

Perineuronal net interactions in modulating adult plasticity and cognitive function
Ilaria Bertocchi (University of Turin, Turin, Italy)

Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
Monika Bijata (Nencki Institute of Experimental Biology of the Polish Academy of Science, Warsaw, Poland)

Perineuronal net and Parvalbumin-expressing interneurons are rescued by the combination of antioxidants and environmental enrichment through MMP9/RAGE mechanism: relevance for schizophrenia
Daniella Dwir (Lausanne University Hospital CHUV, Lausanne, Switzerland)

6-Sulfated Chondroitin Sulfate Contributes to Activity-dependent Clustered Plasticity in the Mouse Barrel Cortex
Gabriele Chelini (University of Mississippi Medical Center, Jackson, USA)

VEGFD-based therapies to preserve neuronal structure and function from degeneration
Daniela Mauceri (Neurobiology Heidelberg University, Heidelberg, Germany)

CAP2 orchestrate actin cytoskeleton in synaptic plasticity and in Alzheimer's disease
Silvia Pelucchi (Leopold-Franzens-University Innsbruck, Austria)

Autophagy activation as a therapeutic strategy for proteinopathy-related cognitive impairment
Elvira De Leonibus (Institute of Biochemistry and Cellular Biology IBBC, Italy)

Anti-GluA3 autoantibodies in frontotemporal dementia induce behavioral dysfunctions dendritic spine alterations
Diego Scheggia (University of Milan, Milan, Italy)

Stimulating microglial glucose metabolism and phagocytosis for post-stroke remyelination and cognitive function recovery
Dandan Sun (University of Pittsburgh, Pittsburgh, Pennsylvania)

Pathfinding During Direct Lineage Reprogramming - Omnes Viae Neuronum Ducunt
Marisa Karow (Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany)

Astrocyte-microglia crosstalk promotes Ascl1-dependent post-ischemic astrocyte plasticity through Na+/Ca2+ exchanger 1
Antonella Casamassa (School of Medicine Federico II University of Naples, Naples, Italy)

Modulating glutamate transmission reduces the reactive astrocyte phenotype in amyotrophic lateral sclerosis
Carola Torazza (University of Genoa, Genoa, Italy)

Proteomics analysis links alterations of bioenergetics, mitochondria-ER interaction and proteostasis in hippocampal astrocytes from 3xTg-AD mice
Laura Tapella (University of Piemonte Orientale, Novara, Italy)

The small GTPase RIT2 acts on the autophagy-lysosome pathway and modulates alpha-synuclein accumulation
Julia Obergasteiger (Université Laval, Québec, Canada)

Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity
Elena Restelli (Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy)

Antibodies-based therapy to overcome intracellular TDP-43 proteinopathy
Silvia Pozzi (CERVO Brain Research Centre, Québec, Canada)

Towards dopamine reinnervation of the dorsal striatum from ventral striatum axons
David Sulzer (Columbia University, New York, USA)

Targeting protein aggregation and the interaction of misfolded protein oligomers with biological membranes. The lesson from squalamine and trodusquemine: from the biophysics to human clinical trials
Fabrizio Chiti (University of Florence, Florence, Italy)

DOPAL initiates αSynuclein-mediated neuronal dyshomeostasis leading to enhanced vulnerability in Parkinson’s disease
Luigi Bubacco (University of Padova, Padua, Italy)

Drug-based synapsin III recruitment allows recovery of functional alpha-synuclein at dopaminergic synapses
Francesca Longhena (University of Brescia, Brescia, Italy)

Systemic inflammation in Treatment Resistant Depression: pathogenetic mechanism and target for treatment
Francesco Benedetti (University Vita-Salute San Raffaele, Milan, Italy)

Dendritic remodeling of hippocampal pyramidal neurons, induced by chronic stress and fast-acting antidepressant ketamine, involves miR-9-5p
Jessica Mingardi (University of Brescia)

Epigenetic mechanisms of glutamatergic function for personalized interventions in neuropsychiatric disorders
Carla Nasca (The Rockfeller University, New York, USA)

Structural Plasticity Induced by Ketamine in Human Dopaminergic Neurons as Mechanism Relevant for Treatment-Resistant Depression
Ginetta Collo (University of Brescia, Brescia, Italy)

An altered extracellular vesicle protein cargo drives the (mis)communication between astrocytes and neurons in ALS
Manuela Basso (University of Trento, Trento, Italy)

Spinal muscular atrophy, more than a motor neuron disease: the contribution of neuromuscular junction dysfunctions to disease progression
Marina Boido (University of Turin, Turin, Italy)

In-vivo and in-vitro evidence supporting the role of mGlu5 receptor as a key regulator of glutamate downstream effects in ALS
Marco Milanese (University of Genoa, Genoa, Italy)

Activation of chaperone-assisted selective autophagy counteracts misfolded protein accumulation in motoneuron diseases
Angelo Poletti (University of Milan, Milan, Italy)

Diverse early-life stress experiences result in differentially altered DNA methylation pattern in the brain and immune system
Valeria Carola (La Sapienza University of Rome, Rome, Italy)

Different short- and long-term consequences to sub-chronic stress exposure in male and female BDNF knock-in Val66Met mice
Alessandro Ieraci (University of Milan, Milan, Italy)

Impact of sub-chronic Stress on Thrombosis
Silvia S. Barbieri (Centro Cardiologico Monzino IRCCS, Milan, Italy)

The arousal-based individual screening model: a translational approach for the study of PTSD
Sebastiano A. Torrisi (University of Catania, Catania, Italy)

Derangements in neurotransmission and their correlate in behavioural alterations during aging: rescue from nutraceuticals and nutrition supplements
Massimo Grilli (University of Genoa, Genoa, Italy)

Transfer of painful sensitivity by gut microbiota transplant: pathophysiological and therapeutic gut-brain connections
Lorenzo Di Cesare Mannelli (University of Florence, Florence, Italy)

Differential expression of Perilipins in brain areas during aging and neuro-degenerative diseases
Stefano Salvioli (University of Bologna, Bologna, Italy)

A structure-based approach to model pharmacological interventions: new molecular entities with anti-inflammatory and anti-aggregating profiles
Cristina Lanni (University of Pavia, Pavia, Italy)

"I like the way you sing" – perception of acoustic cues in mouse courtship communication
Catherine Perrodin (University College London, London, United Kingdom)

Functions of sexual signals in wild house mice
Dustin Penn (University of Veterinary Medicine, Vienna, Austria)

Deciphering the role of gonadotropin-releasing hormone (GnRH) neurons mediating socio-sexual olfactory preference
Mauro Batista da Silva (University of Lille, Lille, France)

Neural plasticity in the Accessory olfactory bulb and its role in controlling reproduction in the mouse
Paolo Peretto (University of Torino, Orbassano, Italy)

Study of neuronal guidance in UBE3A-related neurodevelopmental disorders models by nano/micro-structured platforms
Ilaria Tonazzini (Ist. Nanoscienze-CNR, National Enterprise for nanoScience and nanoTechnology, Pisa, Italy)

Light-sensitive nano and microstructures based on conjugated polymers: optical control of cell fate and physiology
Maria Rosa Antognazza (Center for Nano Science and Technology, IIT@Polimi, Milan, Italy)

Extremely low forces generated by magnetic nanoparticles induce axon outgrowth and neural maturation
Vittoria Raffa (University of Pisa, Pisa, Italy)

Super-resolution microscopy analysis of Aquaporin-4 protein aggregates and actin cytoskeleton in glial cells
Grazia Paola Nicchia (University of Bari, Bari, Italy)

Molecular determinants of excitation/inhibition coordination
Cécile Charrier (PSL University, Paris, France)

Immune-synaptopathies: how the immune system affects synaptic formation
Davide Pozzi (Humanitas University, Milan, Italy)

Studying Cortical development through the lens of human disorders
Gaia Novarino (Institute of Science and Technology – IST, Austria)

New therapeutic approaches for neurodevelopmental disorders
Laura Cancedda (Istituto Italiano di Tecnologia – IIT, Genoa, Italy)

Pre-synaptic and peri-synaptic maladaptive responses induced by acute stress in rat prefrontal cortex
Tiziana Bonifacino (University of Genoa, Genoa, Italy)

Acute ketamine restores glutamatergic alterations and dendritic atrophy in the prefrontal cortex, together with improving fear memory extinction, in a rat model of PTSD
Laura Musazzi (University of Milano-Bicocca, Monza, Italy)

Effects of combined administration of fluoxetine and zinc in a model of chronic restraint stress in mice
Paulina Mistztak (Jagiellonian University Medical College, Kraków, Poland)

Gene expression response of cortical oligodendrocytes to chronic psychosocial stress in an anxious and non-anxious mouse strain
Iiris Hovatta (University of Helsinki, Helsinki, Finland)

Hydroxychloroquine treatment and immune response in Aicardi–Goutières syndrome patients carrying RNASEH2 mutations
Daisy Sproviero (IRCCS Mondino Foundation, Pavia, Italy)

Nutritional overload worsens EAE severity by promoting synaptic damage and neuroinflammation
Alessandra Musella (University of Rome San Raffaele, Rome, Italy)

Neural progenitor cell-astrocyte crosstalk in adult hippocampal neurogenesis
Valeria Bortolotto (University of Piemonte Orientale, Italy)

Clusterin limits the uptake of α-synuclein aggregates by astrocytes: implications for Parkinson’s disease
Isabella Russo (University of Brescia, Brescia, Italy)

Seril-18, a new synthetic molecule, inhibits α-synuclein aggregation in an experimental model of Parkinson’s disease
Marika Cordaro (University of Messina, Messina, Italy)

Does Parkinson's disease begin in the gut? The progression of gut pathology in the c-rel-/- mouse model of Parkinson's disease
Edoardo Parrella (University of Brescia, Brescia, Italy)

Balancing mitophagy and mitochondrial biogenesis to maintain energy metabolism is required for the neuroprotection induced by ischemic brain preconditioning
Maria Josè Sisalli (University of Naples “Federico II", Naples, Italy)

Dopamine Transporter Knock-out Rats (DAT KO) an innovative animal model for dopamine related diseases
Damiana Leo (University of Mons, Mons, Belgium)

Dopamine-dependent HDAC regulation and its role in postsynaptic neurodegeneration
Stefano Espinoza (Istituto Italiano di Tecnologia, Genoa, Italy)

Cell reprogramming approaches for the generation of dopaminergic in vitro neural systems
Massimiliano Caiazzo (Utrecht University, Utrecht, The Netherlands)

The role of dopamine receptors and their alterations in neurodegeneration
Federica Bono (University of Brescia, Brescia, Italy)

Vitamin D deficiency induces chronic pain and microglia phenotypic changes in mice
Serena Boccella (University of Campania “Luigi Vanvitelli”, Naples, Italy)

Factors that influences the neuroinflammatory effects of 3,4-methylenedioxymethamphetamine (MDMA) administration during adolescence and adulthood
Giulia Costa (University of Cagliari, Cagliari, Italy)

The glutamatergic synapse: a chat room for amyloid-beta peptide and the nucleus
Laura D’Andrea (University of Milan, Milan, Italy)

Unravelling the complex role of neuroinflammation in Alzheimer's disease: preclinical evidence using palmitoylethanolamide
Marta Valenza (Sapienza University of Rome, Rome, Italy)

Visual restoration by a photovoltaic retinal prosthesis and optogenetic therapy
Serge Picaud (Vision Institute, Paris, France)

Inducible human photoreceptors for research, development and therapy
Marta Zuzic (Technical University Dresden, Dresden, Germany)

OTX2 in eye physiology and physiopathology: a non-cell autonomous vision
Ken Moya (College de France, Paris, France)

Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy
José Fernando Maya-Vetencourt (University of Pisa, Pisa, Italy)

Computational tools empower the discovery of a novel CBD profile of target interactions in neurodegeneration
Giovanni Ribaudo (University of Brescia, Brescia, Italy)

Cannabidiol modulates human polymorphonuclear leukocyte functions: experimental evidence and clinical implications
Franca Marino (University of Insubria, Varese, Italy)

Studies with cannabidiol in vitro: implications for cerebral ischemia and epilepsy
Elisa Landucci (University of Florence, Florence, Italy)

Cannabidiol and psychiatric disorders: therapeutic insights from preclinical evidence
Maria Scherma (University of Cagliari, Cagliari, Italy)

Molecular dissection of cell division in the human developing brain
Amanda Moccia (The University of Michigan Medical School, Ann Arbor, USA)

Genotoxic stress and TP53 activation in neural progenitors lead to microcephaly syndrome
Gianmarco Pallavicini (University of Turin, Turin, Italy)

Dentate gyrus development requires a cortical hem-derived astrocytic scaffold
Alessia Caramello (The Francis Crick Institute, London, United Kingdom)

Intrinsic genetic control of corticopontine topography by cortical arealization gene Nr2f1
Chiara Tocco (Côte d'Azur University, Nice, France)

Morphological and functional characterization of brain resident macrophages in murine models of ischemic stroke
Joe Kelk (Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy)

Role of miRNAs in the stroke protection associated to remote limb postconditioning
Antonio Vinciguerra (Polytechnic University of Marche, Ancona, Italy)

Artificial intelligence and stroke
Mauro Monforte (Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy)

Head positioning and collaterals in acute ischemic stroke
Susanna Diamanti (University of Milano-Bicocca, ASST-Monza, Monza, Italy)

Neuromorphology of Gender: old and new contributions for the study of brain sex differences
Giancarlo Panzica (University of Turin, Turin, Italy)

Sexual differentiation of microglia in physiology and disease
Alessandro Villa (University of Milan, Milan, Italy)

Of mice, men and women: impact of sex differences on brain and behavior in health and disease
Paola Palanza (University of Parma, Parma, Italy)

Sex and gender brain differences using advanced neuroimaging techniques
Daniela Perani (Vita-Salute San Raffaele University, Milan, Italy)

Differential relation between neuronal and behavioural discrimination during hippocampal memory encoding
Manuela Allegra (Institut Pasteur, Paris, France)

Optogenetic dissection of the neuronal circuits underlying the encoding of sensory information in the mouse cortex
Dania Vecchia (Istituto Italiano di Tecnologia, Genoa, Italy)

Restoration of motor-evoked cortical activity is a distinguishing feature of the most effective rehabilitation therapy after stroke
Anna Letizia Allegra Mascaro (Neuroscience Institute, National Research Council, Pisa,Italy)

Translational aspects of non-invasive brain stimulation techniques to modulate plasticity and behaviour
Marco Cambiaghi (University of Verona, Verona, Italy)

Longitudinal investigations of genetically faithful PD models to identify early dysfunction
Dayne Beccano-Kelly (Cardiff University, Cardiff, United Kingdom)

Bidirectional alterations of nigrostriatal circuit underlie early synaptic and motor dysfunctions induced by α-synuclein
Miriam Sciaccaluga (University of Perugia, Perugia, Italy)

Dissecting the impact of LRRK2 PD mutations at the presynaptic site
Giovanni Piccoli (University of Trento, Trento, Italy)

Lysosome biology in Parkinson’s disease: mechanisms for neuroprotection
Mattia Volta (European Academy of Bolzano EURAC, Bolzen, Italy)

Neuroplasticity and the visual system: the impact of ocular and brain based visual impairment
Lotfi Merabet (Harvard Medical School - Boston - USA)

Musical memories in newborns
Petra Huppi (University of Geneva, Geneva, Switzerland)

Neuronal correlates of affective touch in early infancy
Rosario Montirosso - Eleonora Mascheroni (Scientific Institute IRCCS “Eugenio Medea”, Lecco, Italy)

Early visual training and environmental adaptation for infants with visual impairment
Elisa Fazzi (University of Brescia, Brescia, Italy)

Targeting the epigenome to normalize motivational disturbances after prenatal THC exposure
Anissa Bara (Mount Sinai Hospital, New York, USA)

Characterizing ‘the munchies’; effects of tetrahydrocannabinol (THC) vapour inhalation on satiety and food preference in rats
Catherine Hume (University of Calgary, Alberta, Canada)

Neuroinflammation Drives Changes in Endocannabinoids in the Amygdala Which Contribute to Anxiety-Like Behaviour in a Rat Model of Colitis
Haley A. Vecchiarelli (University of Victoria, Victoria, Canada)

Endocannabinoid signaling deficiency drives emotional and cognitive comorbidities in epilepsy
Roberto Colangeli (Polytechnic University of Marche, Ancona, Italy)

Citron-kinase deletion unveils inherent molecular and functional heterogeneity in dorsal and ventral oligodendrocyte progenitor cells of the mouse forebrain
Enrica Boda (University of Turin, Turin, Italy)

The "Na+/Ca2+" exchanger NCX3 in oligodendrocytes: a potential target for white matter repair
Francesca Boscia (University of Naples “Federico II”, Naples, Italy)

The immune-inflammatory response of oligodendrocytes during neuroinflammation and white matter injury: the role of TLR3 activation
Marta Boccazzi (University of Paris, Paris, France)

TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination in the central nervous system
Ludovico Cantuti-Castelveltri (Technical University of Munich, Munich, Germany)

Microglial vesicles as multimodal mediators of myelin repair and brain recovery after stroke
Marta Fumagalli (University of Milan, Milan, Italy)

Adenosine A2B receptors interact with sphingosine-1-phospate signalling to modulate oligodendrocyte maturation: towards new targets for remyelination in multiple sclerosis
Elisabetta Coppi (University of Florence, Florence, Italy)

Brain resident microglia and infiltrating macrophages: how the ischemic environment influences their recruitment, activation and function
Stefano Fumagalli (Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy)

MED1/BDNF/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia
Livio Luongo (University of Campania “Luigi Vanvitelli”, Naples, Italy)

The lectin pathway of complement activation: a novel pharmacological target for traumatic brain injury
Domenico Mercurio (Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy)

Neurogenesis activation by ischemic preconditioning in neonatal and adult models of hypoxic-ischemic insult
Ornella Cuomo (University of Naples Federico II, Naples, Italy)

Exploring the role of the immune system in ischemic tolerance triggered by conditioning stimuli
Diana Amantea (University of Calabria, Rende, Italy)

Contributions of NCX and EAAT transporters to cell energy balance and survival in neurodegenerative disorders: opportunities and challenges for therapeutic interventions
Vincenzo Lariccia (Polytechnic University of Marche, Ancona, Italy)

Chronic mild stress occludes dopamine-dependent synaptic plasticity in the medial pfc and alters pfc to basolateral amygdala synaptic drive
Jacopo Lamanna (Vita-Salute San Raffaele University, Milan, Italy)

Activity-based anorexia reorganizes the cortical glutamatergic synapse and impairs temporal memory
Francesca Mottarlini (University of Milan, Milan, Italy)

Ethanol neurotoxicity is mediated by changes in AMPA receptor expression, surface localization and functional properties
Elisabetta Gerace (University of Florence, Florence, Italy)

IGF-2 receptor in the auditory cortex improves the precision of recent fear memories and maintains detailed remote fear memories over time
Giulia Concina (University of Turin, Turin, Italy)

The first-line antidiabetic drug Metformin improves the impaired cognitive flexibility in a female mouse model of Rett syndrome
Chiara Urbinati (Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy)

Brief changes in nutritional lifestyle can trigger reversible region- and age-specific effects in DCX+ hippocampal neuroblasts in mice
Fausto Chiazza (University of Piemonte Orientale, Italy)

Imaging the mouse developing auditory cortex
Chiara La Rosa (University of Turin, Turin, Italy)

Detection of SARS-CoV-2 genome and whole transcriptome sequencing in Frontal Cortex of COVID-19 patients
Stella Gagliardi (IRCCS Mondino Foundation, Pavia, Italy)

USVs analysis in murine models of neurodevelopmental disorders
Marika Premoli (University of Brescia, Brescia, Italy)

Use of 50-kHz ultrasonic vocalizations to measure the affective properties of dopaminomimetic drugs in parkinsonian rats
Nicola Simola (University of Cagliari, Cagliari, Italy)

Ultrasonic vocalizations as a tool to assess the validity of mouse models of neurodevelopmental disorders
Susanna Pietropaolo (University of Bordeaux, Bordeaux, France)

Studying socio-affective communication deficits in rodent models for neuropsychiatric disorders through playback studies
Markus Wöhr (KU Leuven, Leuven, Belgium)

Mechanisms of striatal cell signalling in the context of Parkinson’s and Huntington’s Disease
Riccardo Brambilla (Cardiff University, Cardiff, United Kingdom)

Exercise-based rescue strategies in alpha-synuclein induced early experimental parkinsonism
Federica Campanelli (Università Cattolica del Sacro Cuore, Rome, Italy)

Effects of theta-burst stimulation on bidirectional striatal synaptic plasticity in models of Parkinson’s disease and L-Dopainduced dyskinesia
Veronica Ghiglieri (Università Telematica San Raffaele, Rome, Italy)

Modulating L-DOPA-induced striatal neuroinflammation to prevent dyskinesia in Parkinson’s disease
Anna Rosa Carta (University of Cagliari, Cagliari, Italy)

Translational pharmacology in affective disorders: focus on depression
Filippo Caraci (University of Catania, Catania, Italy)

The social determinants of brain and mental health
Sophia Frangou (Icahn School of Medicine, Mount Sinai, New York, USA)

Selecting the right treatment in clinical decision making: neurobiological insights
Mirko Manchia (University of Cagliari, Cagliari, Italy)

Neuropsychology of aggression: single dose effects of catecholaminergic drugs on specific functions
Alessandro Zuddas (University of Cagliari, Cagliari, Italy)

The interplay of autophagy and synapse function
Vassiliki Nikoletopoulou (University of Lausanne, Lausanne, Switzerland)

Impairment of lysosomal functions and autophagy in polyglutamine diseases
Paola Rusmini (University of Milan, Milan, Italy)

Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases
Alessandro Fraldi (University of Naples “Federico II", Naples, Italy)

Role of autophagy/lysososomal genes in neurodevelopmental encephalopathy
Anna Fassio (University of Genoa, Genoa, Italy)

Applications of the RT-QuIC assay for detection and quantification of proteopathic seeds in CSF and brain tissues from Parkinson’s disease and Lewy body dementia patients
Ankit Srivastava (National Institute of Allergy and Infectious Diseases, Hamilton, USA)

International cross-laboratory assessment of the RT-QuIC assay for the analysis of olfactory mucosa samples
Chiara Maria Giulia De Luca (Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy)

Macromolecular chaperones in human cerebrospinal fluid inhibit α-synuclein aggregation in seeding aggregation assays by interacting with oligomeric intermediates
Giovanni Bellomo (University of Perugia, Perugia, Italy)

Chemical chaperones to tackle Parkinson's disease
Jordi Pujols (Autonomous University of Barcelona, Bellaterra, Spain)

MiR-125a-3p impairs oligodendrocyte differentiation and endogenous remyelination: a new potential target for myelin repair
Davide Marangon (University of Milan, Milan, Italy)

Cross-talk between ER-acetylation machinery and microRNA: new insights in the pathogenesis of multiple sclerosis
Nicola S. Orefice (University of Wisconsin-Madison, Wisconsin, USA)

Extracellular vesicle miRNAs track cognitive symptoms in multiple sclerosis patients
Martina Gabrielli (CNR Institute of Neuroscience, Milan, Italy)

MicroRNAs are crucial regulators of inflammatory-driven synaptic dysfunction and disease course in multiple sclerosis
Francesca De Vito (IRCCS INM-Neuromed, Pozzilli, Italy)

Astrocytes in the pathophysiology of AD from reactivity to atrophy and loss of function
Alexei Verkhratsky (University of Manchester, Manchester, United Kingdom)

Time-dependent microglial responses to Aβ challenge: the two faces of neuroinflammation
Sara Merlo (University of Catania, Catania, Italy)

Microbiota modulation counteracts neuroinflammation in 3xTg-AD mice
Laura Bonfili (University of Camerino, Camerino, Italy)

microRNAs: key regulators of astrocyte mediated inflammation in CNS Pathologies
Eleonora Aronica (University of Amsterdam, Amsterdam, The Netherlands)

Analyses of neuromuscular diseases related frameshift mutations in the small Heat Shock Protei B8 (HSPB8) unveil a shared gain of toxic function
Barbara Tedesco (University of Milan, Milan, Italy)

Hsp90-mediated regulation of DYRK3 couples stress granule disassembly and growth via mTORC1 signaling: implications for Amyotrophic Lateral Sclerosis
Laura Mediani (University of Modena and Reggio Emilia, Modena, Italy)

Serine 96 phosphorylation modifies Androgen Receptor stability and function in SBMA models
Diana Piol (University of Trento, Trento, Italy)

Sorting of RNA and RNA-binding proteins in extracellular vesicles
Vito D’Agostino (University of Trento, Trento, Italy)

Crosstalk between oxidative stress and aberrant insulin signalling in the brain: insights for neurodegeneration
Eugenio Barone (Sapienza University of Rome, Rome, Italy)

Engineering proteins as novel candidates for Alzheimer's disease treatment
Cristian Ripoli (Università Cattolica del Sacro Cuore, Rome, Italy)

Oxidative stress as a source of novel predictive biomarkers for Alzheimer's disease: the potential of a conformational variant of p53
Giulia Abate (University of Brescia, Brescia, Italy)

The transcription factor Nrf2 as pharmacological target: in vitro characterization of new nature-inspired molecules
Francesca Fagiani (University of Pavia, Pavia, Italy)